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WHO Develops Lenacapavir Guidelines to Enhance Global HIV Prevention

The World Health Organization (WHO) recently announced the development of new guidelines for lenacapavir and updated HIV testing guidelines. These guidelines are aimed at addressing evolving public health needs, especially for populations disproportionately affected by HIV, and improving access to high-quality HIV prevention and testing services globally.

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A Guideline Development Group (GDG) has been convened by WHO to work on the development of new guidelines on the use of injectable lenacapavir as pre-exposure prophylaxis (PrEP) for HIV. The group will also focus on optimizing HIV testing services for long-acting prevention products. GDG members will review evidence summaries, technical updates, and propose recommendations during a virtual meeting to be held between 28 and 30 January 2025.

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The primary objective of the GDG meeting is to establish normative guidelines for the implementation of lenacapavir as a new HIV prevention product. Specific goals include evaluating the efficacy, safety, and acceptability of injectable lenacapavir as an additional PrEP option for populations at substantial risk of HIV infection. The guidelines will also provide evidence-based guidance on HIV testing protocols for individuals using long-acting PrEP options, including lenacapavir.

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The GDG consists of members from all WHO regions, selected based on technical expertise, roles as end-users, and representation of affected communities. These members serve in their individual capacities rather than as representatives of affiliated organizations and do not receive financial compensation for their contributions to the process.

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WHO encourages transparency and inclusivity by inviting public feedback on the biographies of the GDG members. Interested individuals and organizations can submit comments via email by 20 January 2024. This feedback is crucial for WHO to develop guidelines that reflect diverse perspectives and meet the needs of communities worldwide.

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In related news, recent studies have shown promising results for the use of long-acting injectable lenacapavir in HIV prevention, particularly for women. These developments mark significant progress in the fight against HIV and underscore the importance of ongoing research and guideline updates in the field of public health.

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As global health organizations continue to adapt to emerging health challenges, the latest developments in HIV prevention and testing guidelines represent a crucial step towards providing accessible and effective healthcare services to populations at risk. By prioritizing evidence-based recommendations and inclusive stakeholder engagement, WHO is paving the way for improved public health outcomes and a more resilient healthcare system.

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